Blar i forfatter "Thakkar, Balmukund"

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    • A Biofocussed Chemoprospecting Approach to Drug Discovery: Design, Synthesis and Bioactivity Screening of Diverse Biofocussed Chemical Libraries 

      Thakkar, Balmukund (Doctoral thesis; Doktorgradsavhandling, 2017-04-28)
      With pharma R & D witnessing rising cost, high attrition rates and an overall decline in productivity in recent times, newer approaches are needed for more efficient early phase drug discovery. This thesis describes a new approach, “biofocussed chemoprospecting”. The essence of the approach is to use diverse, yet “bio-like” compounds for efficient hit-finding, along with property filtering and ...

    • Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization 

      Thakkar, Balmukund; Svendsen, John Sigurd Mjøen; Engh, Richard Alan (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-25)
      Cis/trans isomerization of amide bonds is a key step in a wide range of biological and synthetic processes. Occurring through C-N amide bond rotation, it also coincides with the activation of amides in enzymatic hydrolysis. In recently described QM studies of cis/trans isomerization in secondary amides using density functional methods, we highlighted that a peptidic prototype, such as glycylglycine ...

    • Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions 

      Berglin, Mattias; Cavanagh, Jorunn Pauline; Caous, Josefin Seth; Thakkar, Balmukund; Vasquez, Jeddah Marie; Stensen, Wenche Gunvor B; Lyvén, Benny; Svendsen, John Sigurd Mjøen; Svenson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-27)
      Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing ...